Yardeni Mitochondrial Research Lab
2025
Passini FS, Bornstein B, Rubin S, Kuperman Y, Krief S, Masschelein E, Mehlman T, Brandis A, Addadi Y, Huri-Ohev Shalom S, Richter EA, Yardeni T, Tirosh A, De Bock K, Zelzer E. 2025. Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism. Cell Metabolism. doi: 10.1016/j.cmet.2024.12.016.
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Yardeni T, Olali AZ, Chen H, Wang L, Halton JA, Zenab A, Morrow R, Butic A, Murdock DG, Waymire KG, MacGregor GR, Boursi B, Beier UH, Hancock WW, Wallace DC. 2025. Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling. PNAS. doi: 10.1073/pnas.2417252121.
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2024
Gross G, Alkadieri S, Meir A, Itzhaki O, Aharony-Tevet Y, Ben Yosef S, Zenab A, Shbiro L, Toren A, Yardeni T, Jacoby E. 2024. Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose. Leukemia. https://doi.org/10.1038/s41375-024-02257-z
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2022
Schaefer PM, Huang J, Butic A, Perry C, Yardeni T, Tan W, Morrow R, Baur JA, Wallace DC. 2022. Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice. Molecular Metabolism. doi: 10.1016/j.molmet.2022.101560.
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Schaefer PM, Scherer Alves L, Lvova M, Huang J, Rathi K, Janssen K, Butic A, Yardeni T, Morrow R, Lott M, Murdock D, Song A, Keller K, Garcia BA, Francomano CA, Wallace DC. 2022. Combination of common mtDNA variants results in mitochondrial dysfunction and a connective tissue dysregulation. PNAS. doi: 10.1073/pnas.2212417119.
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2021
Yardeni T, Cristancho AG, McCoy A, Schaefer PM, McManus MJ, Marsh ED, and Wallace DC. 2021. An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. PNAS. DOI: 10.1073/pnas.2021429118.
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Kozicz T, Morava E, Yardeni T. 2021. Powering the brain in health and disease. European Journal of Neuroscience; doi: 10.1111/ejn.15230.
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2019
Huizing M, Yardeni T, Fuentes F, Malicdan MCV, Leoyklang P, Volkov A, Dekel B, Brede E, Blake J, Powell A, Chatrathi H, Anikster Y, Nuria Carrillo N, Gahl WA, Kopp JB. 2019. Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases. Kidney International Reports; doi: 10.1016/j.ekir.2019.06.012
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Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, Wu GD, Murdock DG, Wallace DC. 2019. Host mitochondria influence gut microbiome diversity: A role for ROS. Science Signaling; doi: 10.1126/scisignal.aaw3159.
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2018
Yardeni T, Fine R, Joshi Y, Gradus-Pery T, Kozer N, Reichenstein I, Yanowski E, Katz S, Weiss H, Eisenberg M, Shalit T, Plotnikov A, Barr HM, Perlson E and Hornstein E. 2018. High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria. Science Reports; DOI: 10.1038/s41598-017-17878-x.
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2017
Barel O, Christine V Malicdan M, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, Ganelin E, Barshack I, Polak-Charcon S, Nass D, Marek-Yagel D, Amariglio N, Shalva N, Vilboux T, Ferreira C, Pode-Shakked B, Heimer G, Hoffmann C, Yardeni T, Nissenkorn A, Avivi C, Eyal E, Kol N, Glick Saar E, Wallace DC, Gahl WA, Rechavi G, Schrader M, Eckmann DM, Anikster Y. 2017. Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy. Brain; DOI: 10.1093/brain/awx002.
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Malicdan MCV, Vilboux T, Ben-Zeev B, Guo J, Eliyahu A, Pode-Shakked B, Dori A, Kakani S, Chandrasekharappa SC, Ferreira C, Shelestovich N, Marek-Yagel D, Pri-Chen H, Blatt I, Niederhuber JE, He L, Toro C, Taylor RW, Deeken J, Yardeni T, Wallace DC, Gahl WA, Anikster Y. 2017. A novel inborn error of the Coenzyme Q10 biosynthesis pathway: Cerebellar ataxia and static encephalomyopathy due to COQ5 C-Methyltransferase deficiency. Human Mutation; DOI: 10.1002/humu.23345.
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2016
Yardeni T and Hornstein E. 2016. Protocol for high content screening for the impact of overexpressed microRNAs on primary motor neurons. MicroRNA Technologies. Neuromethods, vol 128.. DOI: https://doi.org/10.1007/7657_2016_1.
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2015
Hinderlich S, Weidemann W, Yardeni T, Horstkorte R, Huizing M. 2015. UDP-GlcNAc 2-epimerase/ManNAc kinase, a master regulator of sialic acid synthesis. SialoGlyco Chemistry and Biology I. Topics in Current Chemistry, vol 366. DOI: 10.1007/128_2013_464.
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2014
Leoyklang P, Malicdan MC, Yardeni T, Celeste F, Ciccone C, Li X, Jiang R, Gahl WA, Carrillo-Carrasco N, He M, Huizing M. 2014. Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy. Biomarkers in Medicine; DOI: 10.2217/bmm.14.2.
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2013
Patzel KA, Yardeni T, Le Poëc-Celic E, Leoyklang P, Dorward H, Alonzi DS, Kukushkin NV, Xu B, Zhang Y, Sollogoub M, Blériot Y, Gahl WA, Huizing M, Butters TD. 2013. Non-specific accumulation of glycosphingolipids in GNE myopathy. Journal of Inheritited Metabolic Disease; DOI: 10.1007/s10545-013-9655-6.
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2012
Kakani S*, Yardeni T*, Poling S, Ciccone C, Vincent L, Dorward H, Patzel K, Klootwijk R, Manoli I, Darvish D, Hoogstraten-Miller S, Zerfas P, Tian E, Ten Hagen K, Kopp JB, Gahl WA, Huizing M. 2012. The Gne M712T mouse as a model for human glomerulopathy. American Journal of Pathology; DOI: 10.1016/j.ajpath.2011.12.023.
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Niethamer TK, Yardeni T, Leoyklang P, Ciccone C, Astiz-Martinez A, Jacobs K, Dorward HM, Zerfas PM, Gahl WA, Huizing M. 2012. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Molecular Genetics and Metabolism; DOI: 10.1016/j.ymgme.2012.10.011.
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Yardeni T, Ciccone C, Anikster Y, Kurochkina N, Gahl WA, Huizing M. 2012. Murine isoforms of UDP-GlcNAc 2-epimerase/ManNAc kinase: Secondary structures, expression profiles, and response to ManNAc therapy. Glycoconjugate Journal; DOI: 10.1007/s10719-012-9459-1.
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2011
Yardeni T, Eckhaus M, Huizing M, Hoogstraten-Miller S. 2011. Retro-Orbital Injections in Mice. Laboratory Animals; DOI: 10.1038/laban0511-155.
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Yardeni T, Ciccone C, Patzel K, Anikster Y, Kurochkina N, Gahl WA, Huizing M. 2011. Identification, Tissue Distribution and Molecular Modeling of Novel Human Isoforms of the Key Enzyme in Sialic Acid Synthesis, UDP-GlcNAc 2-epimerase/ManNAc Kinase. Biochemistry; DOI: 10.1021/bi201050u..
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Nemunaitis G, Jay CM, Maples PB, Gahl WA, Huizing M, Yardeni T, Tong AW, Phadke AP, Pappen BO, Bedell C, Allen H, Hernandez C, Templeton NS, Kuhn J, Senzer N, Nemunaitis J. 2011. Hereditary Inclusion Body Myopathy (HIBM): Single Patient Response to Intravenous Dosing of GNE Gene Lipoplex. Human Gene Therapy; DOI: 10.1089/hum.2010.192.
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2010
Shapiro R*, Anikster Y*, Yardeni T*, Korem S, Hartman K, Shamir R, Broide E, Levine A, Bujanover Y, Bercovich D. 2010. DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients. Journal of Human Genetics; DOI: 10.1038/jhg.2010.28.
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Kurochkina N, Yardeni T, Huizing M. 2010. Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria. Glycobiology; DOI: 10.1093/glycob/cwp176.
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2008
Bercovich D, Elimelech A, Yardeni T, Korem S, Zlotogora J, Gal N, Goldstein N, Vilensky B, Segev R, Avraham S, Loewenthal R, Schwartz G, Anikster Y. 2008. Genotype-phenotype correlations analysis of mutations in the phenylalanine hydroxylase (PAH) gene. Annals of Human Genetics; DOI: 10.1007/s10038-008-0264-4
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Bercovich D, Elimelech A, Zlotogora J, Korem S, Yardeni T, Gal N, Goldstein N, Vilensky B, Segev R, Avraham S, Loewenthal R, Schwartz G, Anikster Y. 2008. A Mutation Analysis of the Phenylalanine Hydroxylase (PAH) Gene in the Israeli Population. Journal of Human Genetics; 53: DOI: 10.1111/j.1469-1809.2007.00425.x.